Andrew Huberman· PhD
So the statin does it globally. This other drug called bempedoic acid does it only in the liver. So it has a very similar mechanism to statins. Different enzyme. Not quite as potent, but way fewer side effects.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So the statin does it globally. This other drug called bempedoic acid does it only in the liver. So it has a very similar mechanism to statins. Different enzyme. Not quite as potent, but way fewer side effects.
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so really at least on some level benedict acid is attractive because it's more hepatic selective even if it's less potent
bentonoic acid is a pro drug what that means is by itself it is inactive so when you ingest it it goes to the liver it gets activated and there it is a cholesterol synthesis inhibitor it acts on a different enzyme from statins and what makes bentoic acid special for lack of a better word is that it only inhibits cholesterol synthesis in the liver whereas statins which are very potent Inhibitors of cholesterol synthesis they do so throughout the body because they don't have this pro-drug trick
bendic acid is a prod drug what that means is by itself it is inactive so when you ingest it it goes to the liver it gets activated and there it is a cholesterol synthesis inhibitor it acts on a different enzyme from statins and what makes bempedoic acid special for lack of a better word is that it only inhibits cholesterol synthesis in the liver