Paul Saladino· MD
it's very clear that the human liver only has a certain capacity to to process urea and that's that's how we get rid of nitrogenous bases and so this is the process of you know urea and urea formation and amino acid catabolism and there's pretty darn good studies to suggest that that every individual and this is again this is individual and there's a little bit of a variation between individuals but every individual there is an upper end to how much protein we can consume as humans and beyond that we will not be able to make urea fast as fast as we want to excrete it and you get something called the maximal rate of urea excretion which is prolonged so the there is an upper limit for the maximal rate of urea synthesis so this is the idea of a bull's-eye for protein and that to low is clearly not a good thing and too high is clearly going to overload our bio synthetic cap capacity for urea and our ability to dispose of nitrogen in the human body this is basically what's going on with the biochemistry of rabbit starvation and historically we've seen this an experiment to leave we've seen this I mean historically when Steffensen went into Bellevue Hospital during the first three days he he actually was eating 246-260 for excuse me grams of protein per day which accounted for forty five point three percent of his energy intake and he had symptoms of rabbit starvation nausea diarrhea insomnia and so I mean again without doing the actual biochemistry at the time but historically anthropologically there's good evidence that rabbit starvation exists we know there's an upper limit to protein consumption in humans and this is probably due to the livers limited capacity to produce urea and then if we don't produce urea this is turning into ammonia and then it becomes a dangerous product in the human body so you you could easily get shredded by eating zero fat and tons of protein and four hundred grams of protein a day but that's gonna be dangerous to your body that's not gonna be a good thing so we have to think about this in the context the other thing I would say with regard to the bullseye and the fat equation is that every individual is going to have a certain basil rate of fat oxidation and we know that when people are ketogenic that rate of fat oxidation goes up and this can be measured and with things like metabolic cards specific chambers that are designed to see what our respiratory quotients are and how much fat we're burning and how much fat were actually oxidizing but there are many things that can change the amount of fat that I you or anyone else is oxidizing if I go surfing for a few hours in cold water I'm gonna oxidize a heck of a lot more fat now ted has I believe correctly pointed out that if you eat more fat then the amount of fat that you are oxidizing in a day you will not you will not burn body fat so again this gets to the question of are you looking for performance are you looking to serve hit a punching bag hike you know have mental clarity have optimal hormones or are you looking to have are you looking for weight loss to a certain point right and so if you want to burn fat then yes you should not eat more fat than you can oxidize in a day and that is going to be a very individual thing based on your activity levels whether you're