Positive shifts after psychedelic drug effects may stem from underlying biology like shifts in mu opioid receptors, not just hallucinations.

“There's this like gravitational pull to the idea that, oh, it was the hallucinations. It was the dissociative state. It was the feeling of connectedness. And what we're really saying is that while that certainly could be true, it may be the case that a major source of the positive shift that occurs after the effect of the drug is some underlying biology, like shifts in the mu opioid receptor, a la your experiments with naltrexone, or a change in the underlying neuromodulation that had anywhere from nothing to something to do with the real shift.”