Psilocybin and TMS therapy induce similar connectivity changes associated with antidepressant effects.

“And it's this connectivity between the subgenual anterior cingulate and the default mode network. And so when we do this effective Stanford neuromodulation therapy stimulation, we see a down regulation, the connectivity between them, negatively balanced mood state in the case of depressed individuals and the self-representation of the brain. And you see that same connectivity change occur post-psilocybin, you know, suggesting there's a convergent mechanism”

“And the anti-depressant effects of psilocybin have a particular connectivity change that we also see with our TMS approaches, right? And it's this connectivity between the subgenual anterior cingulate and the default mode network.”