Psilocybin may reduce sensory input gating by de-gating the thalamus, leading to a broader attentional focus.

“But then I've also heard that perhaps it's lack of gating of sensory input. So normally if I'm looking at something, I'm not thinking about the sensation in my right toe unless it's relevant. But if I'm thinking about the sensation in my right toe, I'm generally not thinking about the truck around the corner. So we have these attentional spotlights, but that somehow it creates a more, it adds spotlights. - Yeah, degates the thalamus.”