High-dose psilocybin sessions can facilitate novel rule consideration by disrupting normal thinking and perception, leading to improvements in trauma and depression symptoms.

“So that raises two questions. One is about the basic functioning of the human brain, which is why do you think the brain would ever hold on to rules that don't serve us well? That's one question. And then the second question is, what is it about psilocybin and related molecules in terms of their neurochemistry, in terms of the ways they disrupt thinking and feeling, et cetera, during the session that allow this novel rule consideration phenomenon?”