Andrew Huberman· PhD
there's a shift from the brain being more modular, meaning more segmented like auditory neurons are communicating electrically and chemically largely with other auditory neurons.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there's a shift from the brain being more modular, meaning more segmented like auditory neurons are communicating electrically and chemically largely with other auditory neurons.
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So what happens effectively is that there's a reduction in the modularity, the separateness of function in the brain, and an increase in what's called integration of communication across what would otherwise be disparate brain regions.
And I think the take home message is it expands that connectivity. However, it seems to do so in ways that still allow people to function in their daily lives.
We can say that really simply by saying psilocybin increases communication across the brain.
And what they all point to is more extensive communication between areas of the brain that normally are not as active at the same time while under the influence of psychedelics, such as psilocybin.
it binds nearly selectively to a specific serotonin receptor and it seems to create more what we call resting state lateral connectivity which means more brain areas connected to other brain areas or at least talking to those brain areas after the psilocybin Journey as it's called as opposed to before
what is very clear from the brain Imaging studies that sort before and after resting state task related Etc is that you get more resting State Global connectivity more areas talking to more areas than was the case prior to the use of the Psychedelic
Well, it's more than just blood flow. So connectivity among the hubs of...there's something very interesting going on with respect to brain activity above and beyond blood flow, but blood flow is often considered a marker for level of activity, but the connectivity is an important...and there're also different imaging methodologies that have been used including pretty sophisticated EEG approaches that all seem to hone in on a similar kind of conclusion.