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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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LIVE EVENT Q&A: Dr. Andrew Huberman at the Sydney Opera House — Whalespan

Content›Video›LIVE EVENT Q&A: Dr. Andrew H…

LIVE EVENT Q&A: Dr. Andrew Huberman at the Sydney Opera House

Andrew Huberman53m · 2024-04-19

Claims Made

72

Claims Supported

61

Support Rate

85%

Support rate

61 of 72 claims supported

61 supported11 partial / not

Claims from this content

53

✓Well SupportedBody temperature must drop by 1-3 degrees Fahrenheit to fall and stay deeply asleep, and must increase by 1-3 degrees Fahrenheit to wake up refreshed.✓Well SupportedBrain and body temperature must drop by approximately 1 degree Celsius to fall asleep and stay asleep.✓Well SupportedMDMA's specific effect on social interactions provides a clue for understanding empathy.✓Well SupportedViewing bright light in the 2-3 hours after the temperature minimum will advance the circadian clock, shifting wake-up and sleep times earlier.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

A drop in body temperature approximately two hours before natural wake-up time is a physiological marker that can be shifted.

✓Well SupportedTaking a sauna or hot shower late at night can lead to a compensatory decrease in body temperature, which can improve sleep, provided adequate hydration is maintained.

✓Well SupportedDim red light at night promotes alertness without inhibiting melatonin production or increasing cortisol.

✓Well SupportedChallenging endeavors that stimulate the growth of the anterior mid-cingulate cortex are those individuals would prefer not to do.

✓Well SupportedPsilocybin use increases communication between typically inactive brain areas.

✓Well SupportedA room cooling, warming up, and cooling down before sleep protocol promotes falling asleep, staying asleep, and deep sleep.

◐Partially SupportedIbogaine is a potent psychedelic with significant cardiac risks that can be mitigated by screening with electrocardiograms.

✓Well SupportedMDMA is likely not neurotoxic to serotonergic neurons at appropriate doses and with proper sourcing.

✓Well SupportedAdjusting to a nine-hour time difference involves determining one's temperature minimum and adjusting their schedule two to three days prior to travel with bright light exposure, exercise, or meals.

✓Well SupportedBelieving stress is enhancing can lead to stress being experienced as enhancing for cognitive and physical performance.

✓Well SupportedPsilocybin mimics serotonin by activating serotonin receptors, leading to neuroplasticity in neural circuits related to memory and perception.

✓Well SupportedA sauna protocol of 20 minutes in a sauna at least 176°F (80°C) one to two hours before bed may promote slow-wave sleep.

◐Partially SupportedNeuroplasticity and introspection persist throughout the lifespan.

◐Partially SupportedLight exposure should be timed based on internal body temperature rhythms: avoid light when temperature is decreasing and seek light when temperature is increasing.

✓Well SupportedThe prefrontal cortex regulates and directs brain signals, suppressing context-inappropriate behavior.

◐Partially SupportedStudies on Latter-day Saints show no apparent neurotoxicity from up to 100+ doses of MDMA.

◐Partially SupportedMDMA has potential clinical applications for trauma, but is not yet FDA approved or legal.

◐Partially SupportedViewing sunlight in the middle of the day does not shift the circadian clock but is beneficial for mood and can enhance testosterone and estrogen levels when exposed to skin in healthy, non-burning amounts.

◐Partially SupportedPsilocybin journeys, even if terrifying during the experience, can lead to significant insights if the right support and 'set and setting' are provided.

◐Partially SupportedA certain level of autonomic arousal can bring individuals into an optimal state of focus, referred to as a 'flow state'.

◐Partially SupportedTo avoid disrupting the circadian clock when traveling east, wear dark sunglasses for 2-3 hours before the temperature minimum for the first two days, and seek sunlight 1-2 hours after the temperature minimum.

◐Partially SupportedViewing landscapes with unpredictable features can expand the frame rate and alter the perception of time's passage.

✕Not SupportedUsing MDMA more frequently than once every three months carries a risk of long-term serotonergic toxicities.

◐Partially SupportedRepeated exposure to the same stressor typically leads to releasing less adrenaline over time.

◐Partially SupportedA thermoneutral rinse lowers body temperature by affecting the medial preoptic area of the hypothalamus.

◐Partially SupportedAfternoon sunlight exposure in a new time zone can advance the circadian clock.

◐Partially SupportedThe visual system anchors our frame rate in time, allowing us to distinguish past, present, and future.

◐Partially SupportedTime perception is influenced by the amount of activity in one's day.

◐Partially SupportedTime perception is influenced by the visual system, specifically by focusing on close-up objects versus distant ones.

◐Partially SupportedMDMA's empathogenic component is key for treating PTSD, as it helps resolve confusion about responsibility and fosters self-empathy.

◐Partially SupportedSeeking out safe challenges is beneficial for managing stress.

◐Partially SupportedWatching live aquarium videos can be relaxing and reset the mind.

◐Partially SupportedHabituation to a repeated stressor leads to a decrease in adrenaline release and autonomic arousal.

◐Partially SupportedCold exposure can lead to an eventual increase in core body temperature if one does not stay in long enough to become hypothermic.

◐Partially SupportedIf a repeated stressor decreases life satisfaction or increases psychological stress, adrenaline release and autonomic arousal may increase with subsequent exposures.

◐Partially SupportedPsychedelics and cannabis can distort time perception by increasing serotonin levels.

◐Partially SupportedPsilocybin and LSD are scheduled drugs explored for therapeutic uses in severe depression, smoking cessation, and eating disorders.

◐Partially SupportedEating on the local schedule is a zeitgeber for the circadian clock and can help shift activity and social rhythms.

◐Partially SupportedAndrew Huberman's longevity protocols are derived from existing scientific literature and are not named after him to avoid confusion.

◐Partially SupportedPharmacological agents like caffeine, alcohol, and cannabis have been used to adjust productivity, though their use is not recommended.

✕Not SupportedProlonged cold exposure (e.g., 45 minutes in a cold plunge) can be a very powerful stimulus and should be approached with caution, starting with minimal effective doses.

◐Partially SupportedEngaging in rhythmic physical activity can help dispel excess anticipatory energy and improve focus during tasks requiring fine motor control.

◐Partially SupportedMDMA may help resolve trauma by intervening in the nervous system's confusion about responsibility through self-empathy.

◐Partially SupportedLooking further away captures larger time bins with less resolution, while looking closer in and predicting outcomes increases the frame rate.

◐Partially SupportedArtificial lighting and electronic devices can disrupt natural circadian rhythms, causing many people to experience 'jet lag' without traveling.

◐Partially SupportedLearning is one of the most valuable activities for personal well-being.

◐Partially Supported40 Hz tones may enhance cognitive work by entraining brain circuits involved in logical, analytical, and 'if-then' type thinking.

◐Partially SupportedAndrew Huberman's view on psychedelics has shifted towards therapeutic exploration due to federally funded studies.

◐Partially SupportedPsychedelics and MDMA can allow individuals to experience the full amplitude of emotions while simultaneously reflecting and identifying actionable outcomes with guidance.