Psilocybin mimics serotonin by activating serotonin receptors, leading to neuroplasticity in neural circuits related to memory and perception.

“But, in fact, psilocybin main effect is to mimic serotonin. But it does it in a very specific way because it activates a subset of serotonin receptors in a very strong fashion leading to neuroplasticity at the level of the neural circuits, that is the brain areas and the connections that serve things like memory and perception.”

“What is interesting, and I think important, is to recognize that psilocybin and the structure of psilocybin is very similar to serotonin itself, very similar, but it activates particular receptors.”

“what is psilocybin psilocybin if you look at it chemically looks a lot like serotonin a lot like serotonin and it tickles that is it binds nearly selectively to a specific serotonin receptor and it seems to create more what we call resting state lateral connectivity which means more brain areas connected to other brain areas or at least talking to those brain areas after the psilocybin Journey as it's called as opposed to before”