The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Just like using MDMA to treat PTSD, and we're going to be starting work with psilocybin to treat PTSD, someone could really reprocess their trauma in a way that has lasting effects. And clearly, there's probably something that... You know, reconsolidation of those memories, they are altered, very consistent with our understanding of the way memory works.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
And so this idea that for whatever reason, going into what's probably a highly plastic state like we were talking about earlier, upregulation of brain derived neurotrophic factor in the case of ibogaine, glial derived neurotrophic factor, this highly plastic state and the ability to kind of re-experience memories. And then as you know, we always reconsolidate a memory when we bring it back up, we always reconsolidate it. But reconsolidating it in that state, for whatever reason, may drive a therapeutic effect.