The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the clinical trials on Sil cybin um and to be clear cybin still illegal it's been decriminalized a few places but we're not talking about recreational use we're talking about several therapy sessions and then two without psilocybin then two um 2.5 gram approximately dosages of psilocybin given separately again with therapist present and then follow-up therapy sessions seem to lead to relief of depression in approximately somewhere between 65 and 80% of people
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A high dose of psilocybin (0.215mg/kg) significantly reduced depression severity in a placebo-controlled, double-blind trial of 52 participants with major depressive disorder. Two weeks post-dosing, 54% of participants met remission criteria, a notable improvement compared to only 12% in the placebo group.
A new randomized clinical trial found that psilocybin treatment resulted in a substantial antidepressant effect in people with major depressive disorder. Therapeutic effects persisted for at least 4 weeks.
in one small study involving adults who had depression researchers at the johns hopkins school of medicine found that after just two doses of psilocybin combined with psychotherapy half of the study participants achieved remission of their depressive symptoms for at least one month