Female mice may be more sensitive to rapamycin than male mice.

“as you go higher in dose so 3 times higher than what they originally tested the females still live a little bit longer but the difference between males and females the gap has closed quite a bit so I think that females for whatever reason at a given concentration of rapamycin are just more affected by that amount of the drug”

“one school of thought is that female mice at least we don't know if the is true in any other organism female mice are more sensitive to rapamycin and that could either be that they don't clear the drug as quickly or that for whatever reason and female mice the same amount of rapamycin has a greater emmett or inhibitory effect but that's one school of thought and I kind of think that's right”

“so I think that females for whatever reason at a given concentration of rapamycin are just more affected by that amount”

“my guess is that because we push the dose so high we might have actually taken it too far in the female so one school of thought is that female mice at least we don't know if this is true in any other organism female mice are more sensitive to rapamycin and that could either be that they don't clear the drug as quickly or that for whatever reason and female mice the same amount of rapamycin has a greater mTOR inhibitor effect but that's one school of thought and I kind of think that's right”

“so I think that females for whatever reason at a given concentration of rapamycin are just more affected by that amount of the drug”

“again females had an advantage with rapamycin but both of these numbers are really quite impressive”

“the rapamycin blood content in the female mice was two or three times higher than it was in the male mice so it was higher and stayed up longer”

“i think it's more about effective concentration than it is a male versus female um truly sex-specific response”

“the Texas group showed that the blood concentrations are three-fold higher in females than in males”

“for instance many of our papers we published I think 12 papers now on Rapa and almost always Rapa has been giving a larger percentage increase in females than in males well um the Texas group showed that the blood concentrations are three-fold higher in females than in males we haven't proven that that's why the females live long ER or have a greater percentage increase but it's certainly very plausible”

“in the highest dose that anybody has used which is not in the ITP but um um in another study males had a big effect and females had no effect so the idea is maybe you've over overdosed the females at that stage”

“you know in rapy the sex bias is very in in longevity at least is very dose dependent at the lowest they' done the females live substantially longer than the or put it this way the effect of substantially bigger in females than in males and that difference gradually goes away as you get it to a higher and higher dose and in the highest dose that anybody has used which is not in the ITP but um um in another study males had a big effect and females had no effect”

“Do you recall that in the ITP the females had a much higher plasma level than the males despite consuming the same amount and I I don't remember if Rich had an explanation for why that was the case”