Bryan Johnson· Author
But before they could develop that further, they also discovered rapamy was a powerful amunosuppressant.
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
But before they could develop that further, they also discovered rapamy was a powerful amunosuppressant.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
And it makes a new life as an immune suppressant and certainly if you use it at high enough doses and you really dampen the ability to activate to you can you can impair the immune system and especally Especially if you combine it with cycllosporin or some other anti-inflammatory or or immune suppressant, then it's used for, you know, after organ transplant in those context.
So so FK506 uh Cerolamus has largely pardon me um uh no no no I'm blanking on what FK506's real name is but anyway whatever it's it's largely displaced uh seramus which is RAPA but that said when we used to give it out we were giving 2 to four milligrams a day.
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.