Bryan Johnson· Author
Researchers thought it might be the ultimate cure for many fungal problems such as athletes foot.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Researchers thought it might be the ultimate cure for many fungal problems such as athletes foot.
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
these molecules that these these bacterial products what you you really would call an antibiotic it did come from bacteria were tested you know in many different assays and I actually think and Matt made me correct me I think some of the earlier assays were actually immunological assays even before some of the anti-fungal assays and and that eventually led many decades after to pursuing it as an immunosuppressant
and um this molecule was clearly found to be a very potent antifungal and that made it a a very logical choice for a bacteria to have evolved to produce it right a bacteria is obviously trying to fight uh A fungi and so um you know by inhibiting uh that through through this this molecule uh you know the first thought was hey this might be the next uh you know cure for uh for for athletes foot
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.