A famous study on resveratrol in mice used a diet poisoned with 60% coconut oil, causing liver swelling and respiratory failure, which is not a valid model for aging.

“Even some of the mouse lifespan studies were done incorrectly.”

“so understand they're not really studying aging they're studying a bizarre pathological process where the liver gets so fat that it crushes the lungs preventing breathing and then in addition the paper that they published reported median lifespan there was a statistically significant increase in median lifespan but only in the animals that were on this highly toxic diet now it turns out that when you have the whole curve and you look at other indices of maximum lifespan the resveratrol was not a benefit and when you look at the lifespan effects in the mice that were not on this toxic diet there weren't any”

“paper in nature which was widely misinterpreted over interpreted as a demonstration of a drug that slowed aging was a drug that did not extend maximum lifespan except in mice that were dying of this extremely unusual lipid-specific poisoning”

“I think the evidence that Resveratrol by itself should have been tested was quite weak and the fact the evidence that it works is U very bad it it almost certainly doesn't do anything at least in mice in terms of Aging”

“so I think the evidence that Resveratrol by itself should have been tested was quite weak and the fact the evidence that it works is U very bad it it almost certainly doesn't do anything at least in mice in terms of aging”

“the famous paper was one in which the mice were Poisoned With a 60% coconut oil diet and they weren't dying of Aging they were because their liver swelled up to the point that it crushed their lungs and they couldn't inhale uh they couldn't breathe this is not I believe a pretty good model for the Aging response”

“so the notion that their drug had slowed aging because on the 60% coconut our diet it temporarily extended lifespan was due to the prevention of this extremely bizarre phenomenon”

“it turns out that the mice die because um they were on a 60% coconut oil diet and it's poisonous uh to the extent that it causes the liver to fill with fat and compresses the thorax so that they cannot inhale three or four papers later they published as a obscure paragraph and a discussion section on a paper uh Pearson was the the first author of the second paper that oh by the way all these mice on the coconut all dieet finally we've looked at them they're all dying because of lung compaction due to uh expansion of the liver”