Resveratrol has failed in human trials for conditions like non-alcoholic fatty liver disease and metabolic syndrome, and in the latter, it worsened dysglycemia.

“there have been a few trials with resveratrol in humans that didn't come out so that right on don't be gentle metabolic syndrome you know this there was a trial of metabolic syndrome there was a trial in prostate cancer that and it I mean resveratrol kind of and there was a trial in Nashville D where resveratrol wasn't really that helpful in fact in the there was a trial in prostate cancer in humans where resveratrol was found to worsen androgen precursors and resveratrol is one of this family of molecules that looks a lot like estrogens and so some of the concern that I have around resveratrol is that it is acting as an endocrine disruptor and it this this is suggested by this prostate cancer trial in which it decreased androgen precursors”

“resveratrol also messes with our hormonal precursors right it lowers the HPA it's been shown to worsen metabolic syndrome and some people and cause dis glycemia”

“so resveratrol though it can activate the sirtuin genes has also been shown to decrease androgen precursors and has failed multiple clinical trials”

“there have been a few trials with resveratrol in humans that didn't come out so good right on oh don't be gentle metabolic syndrome you know this there was a trial in metabolic syndrome there was a trial in prostate cancer that and it i mean resveratrol kind of and there was a trial in nafld where resveratrol wasn't really that helpful”

“and then some of the other trials like i said it actually worsened glycemic control in a few trials in patients with metabolic syndrome”