David Sinclair· PhD
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Amazes me how a @jbiolchem paper by @pfizer claiming resv doesn’t activate SIRT1 (a claim disproved) set the field back a decade, ended clinical programs, and was never righted in journal or mainstream news.
but um you know the research is also pretty clear here i want to show a few things which really make this crystal clear i note a lot of studies in the book which is why ben raises this question because these are not common uh commonly talked about i think i know david personally is a great guy but i'm not convinced this compound is good for humans in any way shape or form
i don't think there's any evidence yet that resveratrol is good for you or that sirtuin activators slow the aging process
it status as a cin activator has been questioned by very serious and skilled biochemists the original data on worms has been disconfirmed by a couple of very good Labs
it status as a cin activator has been questioned by very serious and skilled biochemists the original data on worms has been disconfirmed by a couple of very good Labs