David Sinclair· PhD
Rare back-to-back studies @Nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics.
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Rare back-to-back studies @Nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
When Qu et al. tested a SIRT1 variant engineered to be resistant to activation by resveratrol & other STACs (SIRT1-E230K), they found that LCA was no longer able to activate SIRT1. These data essentially prove that LCA works through the same activation mechanism as resveratrol & other STACs — a remarkable finding