We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
I think that most people understand that while indeed resveratrol might have some positive effects on the functioning of our cells that there is very little, if any, direct evidence that resveratrol can increase lifespan.
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I don't think resveratrol increases longevity. At least, I'm not aware of any direct evidence for that in humans.
drinking your body weight and wine a day to get the doses of RIS veratrol that were needed to produce this effect but for whatever reason there was an effect which is if the thing that was going to kill you was your liver being so full of fat that it shot up into your chest so you couldn't breathe um which I've never seen a human no matter how bad their fatty liver has been where that's been the case but if that's if that's the problem you're going to face it's possible at least based on this one Mouse experiment that you were going to live longer but again it turned out that there was no other replication of this in Mouse models that matter
gained a lot of notoriety about 20 years ago when one lab doing one experiment somehow was able to convince some people including uh a very large Pharma company that RIS veratrol increased lifespan now lots of experiments were done that couldn't find that but one experiment was done but it was a it was an interesting experiment I've discussed this at least on two podcasts including one with Rich Miller who runs the ITP the interventions testing program which later tested ratol and found that it did uh categorically nothing in this one experiment that worked
resveratrol is actually a molecule that's been a great failure if you look at the trials with resveratrol it extended lifespan and lower in vertebrates like C elegans which is a little worm and perhaps in yeasts and it had some data in mice which were compelling but in humans it's failed miserably
I remember those days where Resveratrol was the thing right for longevity and everybody was not everybody a lot of people were buying R virtual and there studies with mice showing that increased 50% longevity in mice so therefore forless do it in humans well as you probably know a lot of people started to take in ver virtual when they were 50 and they're dead now you know it didn't incate it doesn't increased longevity in humans right
resveratrol was the thing right for longevity and everybody was not everybody a lot of people were buying resveratrol and their studies with my show and that increased 50 longevity in mind so their let's do it in humans well as you probably know a lot of people started to take in resveratrol when they were 50 and they're dead now you know it didn't increase it doesn't increase longevity in humans right