Andrew Huberman· PhD
one of the major problems we have with aging developing or development of aging-related issues with muscle, is the fact that we lose fast twitch fibers preferentially.
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one of the major problems we have with aging developing or development of aging-related issues with muscle, is the fact that we lose fast twitch fibers preferentially.
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And one of the things that is a hallmark of aging is a selective reduction in fast-twitch fibers.
Fast-twitch fibers, unless you're doing something of high force or going, not be used. And they're not going to be kept around. And that's a problem because when you look at things like the need for leg strength through aging, the ability to catch yourself from a fall, these things are incredibly important.
what is the Hallmark of aging on the muscle it is atrophy of the type two muscle fiber that's the Hallmark fast twitch fast twitch muscle fiber
We know that you will preferentially lose fast twitch muscle fibers with aging and the only way to activate or preserve those fast muscle fibers is very high Force demand
why maintaining fast-twitch muscle fibers is critical as we age
you see virtually no reduction in slow twitch fibers with aging you see no reduction in size in fact there's some more than a few papers showing a hypertrophic effect of soled fibers of agent there is no loss in V there's no loss in specific tension which is like force per unit of size there's no loss in power
because fast fibers require Force production and you generally don't get high Force production in activities of daily living then those fibers go unutilized for long stretches of time eventually they go away
you see a dramatic reduction in fast tge fibers and you actually don't see um a drop of power and so there's nothing internal to the muscle fiber that's going down so another way to say this is if you take the problem it's the fiber size the atrophy of fastr fibers is the almost exclusive the problem with aging in muscle
you see very little loss of function in SLO fibers through aging regardless of exercise or not
you see a dramatic reduction in fast tge fibers and you actually don't see um a drop of power
you have got to maintain fast twitch fiber size
it's the fiber size the atrophy of fast s fibers is the almost exclusive the problem with aging in muscle
the opposite happens when we get older you get smaller type two fibers actually and that is where most of the muscle loss with age actually comes from
you see very little loss of function in SLO fibers through aging regardless of exercise or not
As you age, the type-1 fibers are more well preserved, whereas the type-2 fibers, there's even what's called apoptosis, which has been shown as a loss of fibers. But certainly there's a diminishment where the fibers get smaller and smaller.
Yes. And so definitely there's evidence to suggest that there's progressive loss of these fast twitch muscle fibers, maybe, mainly, or sorry, maybe, mainly due to the inherent aging process.