Paul Saladino· MD
𝐒𝐞𝐞𝐝 𝐨𝐢𝐥𝐬 𝐥𝐨𝐰𝐞𝐫 𝐜𝐡𝐨𝐥𝐞𝐬𝐭𝐞𝐫𝐨𝐥 𝐛𝐲 𝐜𝐚𝐮𝐬𝐢𝐧𝐠 𝐝𝐚𝐦𝐚𝐠𝐞 𝐭𝐨 𝐲𝐨𝐮𝐫 𝐥𝐢𝐯𝐞𝐫.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
𝐒𝐞𝐞𝐝 𝐨𝐢𝐥𝐬 𝐥𝐨𝐰𝐞𝐫 𝐜𝐡𝐨𝐥𝐞𝐬𝐭𝐞𝐫𝐨𝐥 𝐛𝐲 𝐜𝐚𝐮𝐬𝐢𝐧𝐠 𝐝𝐚𝐦𝐚𝐠𝐞 𝐭𝐨 𝐲𝐨𝐮𝐫 𝐥𝐢𝐯𝐞𝐫.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Polyunsaturated fats like omega-6 linoleic acid in seed oils lower LDL by creating oxidative stress in the liver which leads to activation of a post-ER presecretory proteolysis pathway (PERPP) that degrades APOB100, lowering VLDL secretion. (PMID: 15124019)
when you feed animals and animal models excess amounts of polyunsaturated fats predominantly in seed oils but also occurring in things like fish oils you do see oxidative stress in the liver which degrades apov 100