GLP-1 analogues act in the brain's hypothalamus to reduce hunger and in the gut to increase gastric distension.

“my understanding is that glp1 acts at the level of the brain the hypothalamus to reduce hunger but also at the level of the gut to give the sensation of more gastric distension”

“it's almost entirely reduced appetite and it's almost entirely incurring at the level of the the brain which neurons it's thought that the key targets of of uh these drugs are neurons in these two regions one's called the nucleus of the solitary tract and the other one's called the area Posta”

“and there's a similar peptide made in mice and in humans that suppresses appetite — if you would could you tell us — what is known about how glp1 Works to suppress appetite where in the body indor brain sure”

“if you have a slow metabolism OIC is not going to help because it doesn't incre your increase your metabolic rate it is a very powerful appetite suppressant”