Now that was always assumed to be due to some metabolic need that was triggered by the sleep deprivation or by the poor sleep. But in reading over this study, some of the more important points made by the authors relate to the fact that well, sleep is known to have incredibly important effects on brain and body, for a variety of systems, immune system, neural functioning, et cetera. This very organized sequence of particular forms of metabolism being active during particular phases of sleep, which are very, very well orchestrated, as we know, slow wave sleep, and REM sleep being orchestrated in 90 minutes, so-called ultradian cycles and so on and so forth, is thought to of perhaps set up the brain and body to be able to regulate itself in the waking hours. And therefore, when people are sleep deprived or deprived of certain forms or states within sleep, such as rapid eye movement sleep, that it creates a disruption in a particular set of metabolic pathways.