Neuroplasticity and neural reorganization primarily occur during deep sleep and REM sleep.

“neuroplasticity brain rewiring happens in the middle of the night while you're asleep”

“the actual changes in the nervous system the strengthening and weakening predominantly of connections between neurons that underly learning do not occur during the focusing and learning or rather the exposure to the material but instead during deep sleep and sleep-like states and again I've done a lot of podcasts and talked a lot about tools for getting better sleep but I just want to remind everybody that the actual reordering of the connections the strengthening of connections between neurons that underly learning the weakening of those connections occurs during sleep in particular during rapid eye movement sleep which tends to predominate in the latter half of the night”

“when during either your states of alertness or sleep does the remodeling of neural connections occur I like to think this is a pretty easy one okay the answer is during sleep”

“There was a question that asked whether or not these really deep biological mechanisms around wakefulness, time of waking, sleep, et cetera, were subject to neuroplasticity. And indeed, they are. Some of that plasticity is short term. And some of it is more long term.”

“it is during sleep that we reorganize our neural connections and actual neuroplasticity occurs the stimulus is provided in wakefulness and focus and attention and but the actual rewiring occurs during sleep deep sleep and rapid eye movement sleep”

“A lot of the rewiring of neural connections actually occurs during rapid eye movement sleep and deep sleep. You can't just focus and just work infinitum. You need sleep. You need rest for the rewiring to occur.”