Andrew Huberman· PhD
directly they work by targeting an enzyme um very high in the synthetic pathway of cholesterol production enzyme is called HMG COA reductase
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
directly they work by targeting an enzyme um very high in the synthetic pathway of cholesterol production enzyme is called HMG COA reductase
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Total cholesterol is different from LDL. Statins specifically lower LDL in the blood by increasing LDL receptor expression in the liver.
statin drugs which hopefully we're going to talk about today work is that by inhibiting the production by starving the liver of cholesterol by inhibiting the production of cholesterol in the liver the liver is essentially starving for air quote-unquote the liver is starving for LD this liver is starving for cholesterol it puts more LDL receptors on the surface of the liver and it says give me some cholesterol so that I can breathe and make things I need and it pulls more LDL out of the bloodstream
statins are specifically designed to increase LDL clearance from the liver by decreasing liver synthesis of cholesterol
the one cell we really want to do it in is the liver because that's the cell that has the greatest propensity to upregulate ldl receptors that can clear our apob containing particles so statins do that
so obviously a type of drug that inhibits the synthesis of cholesterol which is its direct action but the money may come more from its indirect action which increases the ldl receptor on the on the liver and you're pulling that apob bearing particle out of circulation and you're having this pretty pronounced effect in terms of ldl c and apob reduction second really now only to pcsk9 inhibitors
so the statins actually reduce ldl particles in the circulation by up regulating the ldl receptor at the surface of the hepatocytes so the density of the ldl receptor at the surface of the hepatocyte is super important the more ldl receptor you have the higher the catabolism of april b containing lipoproteins will be because apob binds to the to the ldl receptor