Paul Saladino· MD
i think there are a few things more important than nitric oxide at the level of the endothelium and we know that pleiotropic mechanism of statins probably has to do with nitric oxide
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
i think there are a few things more important than nitric oxide at the level of the endothelium and we know that pleiotropic mechanism of statins probably has to do with nitric oxide
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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I think that this is exactly the mechanism that we're starting to see with statins what people might consider to be a pleiotropic effect is that there's something else going on there having to do with nitric oxide metabolism and maintenance of the ability of arteries to distend with proper endothelial nitric oxide synthase function