Lipophilic statins are more likely to cross the blood-brain barrier and suppress cholesterol production, increasing dementia risk.

“so then the lipophilic statins do seem you know particularly in high doses are gonna be much more likely to cross into the brain and then suppress cholesterol production and that you know and you're gonna need that cholesterol for a proper cell health and your brain if you don't have it then you have an increased risk of dementia”

“so if you're worried about statins getting into the brain you might want to choose the hydrophilic ones or so”

“subsequent anes is shown all statins get into the brain ultimately once you have a steady state Statin level in the blood they all will get into your brain and they all have the ability to suppress cholesterol synthesis in the brain”