Lipophilic statins may have a greater propensity to enter the brain compared to hydrophilic statins.

“all statins can get into the brain 810 cross the blood-brain barrier but the statins that cross it much easily are the lipophilic statins because they have to pass a lipid membrane the blood-brain barrier so a tour of a statin simvastatin get into the brain more easily than do lovastatin simvastatin and they tour the statin wait say that again the feel like statins easier to probably be the worst whereas Prevost at and it'd be would be far less ad would we resist and have that flu the statins sort of a water soluble statin is probably more in the class of resuming and what our live alone would be the same you say yeah non lipophilic statin”

“where lipophilic statins might be have a little more bit propensity to do that than hydrophilic statins so there are other issues at play that would influence where you're going”

“cuz early on if you go back probably maybe even listen to the podcast you and I did in 2018 I believe we were talking about hydrophilic and lipophilic statins and the lipophilic ones can pass right through the barrier”

“subsequent analyses is shown all statins get into the brain ultimately once you have a steady state Statin level in the blood they all will get into your brain and they all have the ability to suppress cholesterol synthesis in the brain”

“these studies were almost all done in the setting of trying to determine if lipophilic versus hydrophilic statins were more less or better and the answer always emerged it didn't seem to matter which of course makes sense if you understand now that they probably all cross the blood brain barrier”