Paul Saladino· MD
when you inhibit HMG co-reductase your body cannot make coins on q10 which is down stream from cholesterol and then you get a deficiency in that in the membrane
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when you inhibit HMG co-reductase your body cannot make coins on q10 which is down stream from cholesterol and then you get a deficiency in that in the membrane
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as we talked about with the mevalonate pathway downstream of hmg-coa is coenzyme q-10 when we inhibit the production of the next steps in the pathway squalene other things there are many compounds made from hmg-coa besides cholesterol
these are drugs that inhibit a an enzyme called hmg-coa reductase which is part of the mevalonate pathway the mevalonate pathway is the pathway in our body by which we synthesize cholesterol
statins are drugs that inhibit a an enzyme called hmg-coa reductase which is part of the mevalonate pathway
statins are HMG COA reductive Inhibitors this is an enzyme in something called the mevalonate pathway and it starts with acetal COA you see HMG COA here goes to mevalonate HMG COA reductase stattin do that
Statins are hmg-coa reductase inhibitors this is an enzyme in something called the metallonic pathway and it starts with acetyl coa you see hmg-coa here goes to mevelani hmg coe reductase statins do that
statins mechanism here they block the enzyme HMG COA reductase we talked about this which inhibits that whole neonate pathway
statins inhibit hmg-coa reductase that is an enzyme that is prior to the bifurcation of the cholesterol synthetic pathway