Andrew Huberman· PhD
And so, it seems to me that the requirements, this is an AND gate type arrangement, you need neuromodulator present, you need a particular pattern of firing in the neurons so that there's a chance that they wire together, or wire apart, whatever you're trying to drive the circuit to do, and you need a strong intention. You need that friction and focus from the person. - Yeah. - So, on the one hand, it seems like we need specificity, and that's where we're going to go next, talking about the vagal stimulators that you work on, and are getting such incredible results with. But on the other side of the coin, it's like you just need these chemicals present. - Yeah. - So, for instance, if I want to learn something, and I'm going to focus as hard as I can on it, I will occasionally take, you know, these are very low dosages, 2 milligrams of nicotine. I don't do this lately. I just did an experiment last year. I didn't like it, because it made my throat spasm a little bit when I wasn't - Mm-hmm. - ... taking the gum. - The muscarinic receptor business explains that. So, I stopped. But yeah, it provides a stimulant effect. But here's my question, if we just globally raise acetylcholine by taking a drug, do you get the opposite effect as you get from globally decreasing acetylcholine activity by taking a drug, which you said makes you forget?