The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
most of the studies of inositol have explored very high dosages, like even 10 or 12 grams per day, which I must say seems exceedingly high and they do report that some of the subjects in those experiments actually stop taking the inositol because of gastric discomfort or gastric distress as it's called.
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if you look at the human studies on myo-inositol that are out there and in particular focus on the human studies, what you'll find is that the dosages that are often used are tremendously high, things like five grams, eight grams, 18 grams of myo-inositol taken throughout the day. I don't know how people stomach that. And in fact, many people drop out of those studies because of gastric discomfort. And yet I also wonder how people tolerate it because it has somewhat of a sedative effect and this kind of anti-anxiety effect.
And as I discussed in our episode about obsessive-compulsive disorder, inositol has been used at high dosages, again, I should say myo-inositol has been used at high dosages, at levels of even 10, 18 grams, those are massive dosages by the way, to deal with certain symptoms of OCD to limited success. And I should mention that high dosages of 10 or 18 grams of inositol can cause a lot of gastric discomfort, et cetera.