David Sinclair· PhD
Participants with accelerated biological aging showed a GrimAge effect of -0.236 years/year. Normal agers: -0.013.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Participants with accelerated biological aging showed a GrimAge effect of -0.236 years/year. Normal agers: -0.013.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
The bulls: daily Centrum Silver slowed PCPhenoAge by ~2.6 months/year and PCGrimAge by ~1.4 months/year.
if you're over 65 and not eating well, a $3/month generic multivitamin has better published evidence than any longevity supplement selling at 10 to 50x the price.
Older adults taking a daily multivitamin for 2 years reduced their pace of epigenetic aging by 0.1–0.2 years compared with placebo.
The effect was strongest in people with accelerated biological aging.