Consuming substances that increase dopamine, like Macuna Pruriens, can lead to a subsequent 'crash' or reduction in baseline dopamine levels.

“However, I should mention that any time you consume a substance that increases dopamine by mimicking dopamine or acting as a direct precursor to dopamine, there's almost inevitably a crash or a reduction in the baseline in dopamine that we referred to previously.”

“Mucuna pruriens is actual L-dopa. It's 99% L-dopa, which is a prescription drug that is given for Parkinson's and for other purposes where increasing dopamine is important. I don't recommend mucuna pruriens. I'm not saying that no one should take it, but I don't take it. And I don't recommend it because it tends to so potently and acutely increase dopamine, that there's a pretty substantial crash afterwards.”

“Mucuna pruriens is actually 99% l-DOPA, the precursor to dopamine. I don't necessarily recommend Mucuna pruriens. It tends to make people very dopaminergic-- drive, drive, drive, drive, motivated, and then crash. Again, depleting that pool.”