Testosterone therapy at 120mg/week can have adverse effects including acne, skin pathologies, bruising, hair loss, mental status changes, cardiovascular issues, ferritin buildup, fertility problems, and lipid changes.

“Every organ system in the body. So this is when you really have to be at least well-versed in every organ system, not just the gonadal genital system. You need to have dermatology prowess. Acne is very common change. Lots of different skin pathologies or even bruising can be related to hormone replacement. Hair loss is very common to see as well. Mental status changes. It could occasionally even induce as a manic or a bipolar episode because testosterone is also dopaminergic. And then a cardiovascularly not just in the heart, but also concerns for like microvascular ischemic disease. Ferritin buildup because the estrogen also increases. And then fertility concerns as well and lipid concerns too. So you really have to be hematologist, dermatologist, cardiologist, lipidologist, the whole 9 yards.