Starting testosterone replacement therapy (TRT) with low or no aromatase activity can lead to increased free thyroid hormones and potential tachycardia due to decreased thyroxine binding globulin. — Whalespan
Starting testosterone replacement therapy (TRT) with low or no aromatase activity can lead to increased free thyroid hormones and potential tachycardia due to decreased thyroxine binding globulin.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“If they're taking testosterone and they have very little estrogen, then you're going to decrease the binding protein, also known as thyroxine binding globulin, which binds active thyroid hormones. So if you start TRT and you either have low aromatase activity or no aromatase activity-- no conversion to estrogen-- then your free thyroid hormones will go up.”
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