Andrew Huberman· PhD
That throat aggravation you feel when you don’t take it is because of the activation of muscarinic ACh receptors.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
That throat aggravation you feel when you don’t take it is because of the activation of muscarinic ACh receptors.
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it it doesn't just hit the nicotinic receptors it'll also hit the muscarinic acetylcholine receptors and that's one reason why if you do take nicotine gum or use nicotine gums or pouches what you'll notice is when you don't use it you'll feel as if your throat is a little um mildly irritated and and then you take it and it and it relaxes it interesting and this is one of the more subtle but powerful ways in which it is habit forming is that people feel like they're more verbally fluid they can breathe easier when they're taking nicotine