When cells are overloaded with fat, they cannot metabolize glucose, leading to pyruvate accumulation, NAD+ depletion, and increased lactate production, which is invariably seen in type 2 diabetes.

“so the glucose will go through glycolysis and it will end at the stage of pyruvate and pyruid starts to accumulate uh because it's you cannot proceed further to the this render cycle block this accumulation of pyruvate something has to happen with it and because the production of pyruvate consumes NAD and produces nadh the cell will say I need my NAD in order to to live if I if my NAD levels the oxidized uh version of the cofactor nicotinamide I don't know if I if my levels of energy drop too much I'm gonna die so I need my nadh oxidized back into NAD what can I use well pyruvate is the emergency oxygen but guess what after you use Spirit you get lactate and you you see this invariably in every single case of type 2 diabetes they have uh higher than uh optimal levels of lactic acid”