The GLP-1 pathway was explored for diabetes treatment because it boosts natural insulin release, acting as a safer amplifier than direct insulin injections which carry a risk of hypoglycemia.

“and the reason is that you know you can treat diabetes with insulin injections but insulin is dangerous right because if you inject too much insulin you can kill yourself by making yourself hypoglycemic right so this have to be very careful but the thing about the incretin effect is it's not causing insulin release directly but it's rather boosting the natural insulin release that comes when glucose is higher in your blood so it's sort of an amplifier on the natural insul insulin release”