Andrew Huberman· PhD
The one in the gut is actually tryptophan hydroxylase-1. Some of my published work hypothesized that it might actually be repressed by vitamin D because it has a sequence.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The one in the gut is actually tryptophan hydroxylase-1. Some of my published work hypothesized that it might actually be repressed by vitamin D because it has a sequence.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
While the precise level of vitamin D needed to effectively boost serotonin production through TPH2 isn't fully established, we do know that more than 70% of the U.S. population has vitamin D levels below 30 ng/ml, which is considered the threshold for sufficiency.
Vit. D and tryp. MAY be able to get around this.