Andrew Huberman· PhD
Some people may need 10,000 units of vitamin D to get the same blood level as somebody else with 1,000. And that's because there's different vitamin D receptors, and they're different genetically determined.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Some people may need 10,000 units of vitamin D to get the same blood level as somebody else with 1,000. And that's because there's different vitamin D receptors, and they're different genetically determined.
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Some people need 1,000 units of vitamin D, some people need 5,000, some people need 400 micrograms of folate, some people need 4,000 micrograms of folate.
So if you have a polymorphism, an alternate form of some gene, that means that you need more magnesium than the next fellow or more vitamin D than the next fellow, then you'll wanna know that.