Vitamin D directly regulates neuronal inflammation, amyloid clearance, neurotrophic factors, and oxidative stress pathways by controlling gene expression.

“Mechanistic data illustrate vitamin D’s direct role in regulating neuronal inflammation, amyloid clearance, neurotrophic factors, and oxidative stress pathways. Vitamin D directly regulates gene expression within the nucleus.”

“Vitamin D’s brain-protective effects may stem from its unique role as a steroid hormone, structurally akin to estrogen and cortisol. It regulates thousands of genes, many of which govern critical brain processes—an effect consistent with findings from randomized controlled trials showing improvements in cognitive function and IQ scores in older adults.”

“Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control.”

“So it's a steroid hormone, and it's controlling a thousand genes, lots of them in your brain.”

“There's a lot of mechanisms by which vitamin D affects the brain. So it plays a role in immune the immune modulation, the immune response. We could go on and on about that. It plays a role in neuroplasticity and also amaloid beta clearance among other things. Um I mentioned it's over a thousand genes it's regulating. Many of those genes are in the brain.”

“And it's not a surprise because vitamin D is affecting like I said over a thousand genes. You know, genes that are obviously involved in bone homeostasis, but also immune function, bone um brain function, just a lot of different processes that are important for regulating the aging process.”