Effect of longevity interventions on epigenetic clocks: Strongest: 1. Arthritis therapy/an

Well SupportedAnti-TNF therapy, Metformin, and Ketamine are pharmacological interventions that significantly decrease or slow down biological aging.

Partially SupportedInterventions with no effect on epigenetic age include rapamycin, omegas, exercise, Vitamin B, CR/IF, Ozempic, and Follistatin.

Partially SupportedBlood biomarkers such as CystatinC, HBA1c, CRP, ALK, and triglycerides can serve as proxies for DNA methylation age and diet.

Partially SupportedKetamine may reduce methylation at specific sites within the BDNF gene, potentially improving brain health.