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Why palmitoleic acid is such an important biomarker — Whalespan

Content›Video›Why palmitoleic acid is such…

Why palmitoleic acid is such an important biomarker

Peter Attia14m · 2021-05-17

Claims Made

21

Claims Supported

20

Support Rate

95%

Support rate

20 of 21 claims supported

20 supported1 partial / not

Claims from this content

17

✓Well SupportedElevated plasma triglycerides are associated with higher levels of palmitoleic acid (POA).✓Well SupportedElevated plasma triglycerides and palmitoleic acid (POA) can indicate impending health trouble before blood sugar rises.◐Partially SupportedConverting saturated fatty acids via SCD-1 increases lipogenesis, leading to more lipid production and export from the liver.◐Partially SupportedObesity may be a protective mechanism and a result of metabolic illness, with inflammation exacerbating the condition.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

The body converts excess dietary fat into cholesterol esters and triglycerides, which are then exported from the liver.

✓Well SupportedThe enzyme SCD-1 converts palmitic acid into palmitoleic acid.

◐Partially SupportedThe liver converts excess energy into fat and exports it via VLDL as a short-term protective measure when carbohydrate tolerance is exceeded.

◐Partially SupportedHigh carbohydrate consumption leads to elevated C16:0 saturated fat and increased VLDL production via the SCD-1 pathway.

◐Partially SupportedCarbohydrates can lead to increased insulin, which in turn increases sterol CoA desaturase (SCD1) activity in the liver.

◐Partially SupportedPalmitoleic acid is formed from palmitic acid through the enzyme delta-9 desaturase (SCD1).

◐Partially SupportedSterol CoA desaturase (SCD) activity is an independent marker of triglyceridemia and abdominal adiposity, which are associated with insulin resistance.

◐Partially SupportedElevated sterol CoA desaturase activity can indicate potential health concerns even with normal blood sugar.

◐Partially SupportedNormal blood sugar does not necessarily mean a person is healthy.

◐Partially SupportedThe liver converts excess energy into fat and exports it to protect itself from an abundance of nutrition.

◐Partially SupportedFructose and glucose entering the liver through GLUT5 and GLUT2 transporters increase SCD-1 activity.

◐Partially SupportedPalmitoleic acid (POA) is an underappreciated health predictor.

◐Partially SupportedThe body's conversion of saturated fats into palmitoleic acid may be a protective mechanism.