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186 - The Opioid Crisis with Patrick Radden Keefe — Whalespan

Content›Video›186 - The Opioid Crisis with…

186 - The Opioid Crisis with Patrick Radden Keefe

Peter Attia2h 22m · 2021-12-06

Claims Made

202

Claims Supported

116

Support Rate

57%

Support rate

116 of 202 claims supported

116 supported86 partial / not

Claims from this content

48

◐Partially SupportedPeter Attia was prescribed 20mg of Oxycontin twice daily for back pain in 2000 and increased his dosage to nearly 400mg per day within four months.◐Partially SupportedA daily dose of 320 milligrams of Oxycontin can numb emotional pain.◐Partially SupportedA daily dose of 300mg of Oxycontin is potentially lethal if taken by an unhabituated individual.◐Partially SupportedThe speaker took Percocet for a week for a dental issue seven years after stopping Oxycontin without escalating use.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

OxyContin was marketed as a drug for moderate pain, and unusually, a stronger rather than weaker opioid was used and marketed for this purpose.

◐Partially SupportedThe United States Attorney for Maine warned physicians in early 2000 that OxyContin was dangerous, causing deaths and overdoses.

◐Partially SupportedPurdue Pharma officials, not the FDA, were responsible for the claim about OxyContin's reduced abuse liability in the package insert.

◐Partially SupportedPeter Attia experienced a severe back injury in medical school causing a herniated disc and extreme pain.

◐Partially SupportedPhysiological dependence on Percocet can occur after one week of use, but stopping may not cause significant long-term issues.

◐Partially SupportedVioxx was used to manage pain and break the cycle of pain, allowing for physical therapy and eventual freedom from pain medication.

◐Partially SupportedPurdue promoted OxyContin for long-term pain management, implying it was not a last resort.

◐Partially SupportedTime-release opioid drugs can produce a significant euphoric high.

◐Partially SupportedPhysicians perceived oxycodone as more benign and less stigmatized than morphine, leading to its use in non-cancer pain.

◐Partially SupportedPenicillin was a significant game-changer in World War II.

◐Partially SupportedSubstances like opioids possess immense power, which is compounded by social and situational factors, making recovery challenging.

◐Partially SupportedStudying Purdue Pharma and the Sackler family provides context for understanding the magnitude of the opioid crisis.

◐Partially SupportedThe transition from prescription opioids to potent synthetic opioids like Fentanyl in social settings presents a significant risk.

◐Partially SupportedMany individuals who abuse heroin or fentanyl may have started with prescription opioids.

◐Partially SupportedInfections from IV drug use can be life-threatening consequences.

◐Partially SupportedReturning to an environment that facilitated drug use poses a significant risk for relapse.

◐Partially SupportedA rapid, forced taper of prescription opioid painkillers may drive patients to the black market.

◐Partially SupportedToxicity reports for Oxycontin overdose victims often show the drug mixed with other substances.

◐Partially SupportedSome individuals prescribed Oxycontin find it does not last as long as expected or become dependent, leading them to chew pills for faster pain relief.

◐Partially SupportedThe warning on Oxycontin not to crush pills may inadvertently function as an instruction for misuse.

◐Partially SupportedOxyContin was released in early 1996.

◐Partially SupportedTolerance to time-release opioids can develop rapidly, leading to a need for increased dosage.

◐Partially SupportedPain perception varies regionally, with people in northern Europe reporting lower pain levels than those in southern Europe for the same stimulus.

◐Partially SupportedPharmaceutical sales representatives were incentivized to increase opioid dosages.

◐Partially SupportedThe majority of current opioid overdose deaths are attributed to heroin and fentanyl, rather than prescription painkillers.

◐Partially SupportedThe opioid crisis has resulted in at least half a million deaths from opioid overdoses since the mid-to-late 1990s.

✕Not SupportedThe production and marketing of Oxycontin were problematic due to user base expansion and risk downplaying.

◐Partially SupportedInjecting the incision site with marcaine before cutting, followed by aggressive postoperative NSAID use, can help avoid narcotics for incisional pain.

◐Partially SupportedOxycontin was developed as a time-release version of hydrocodone, similar to MS Contin.

◐Partially SupportedAfter 2010, there was a significant increase in Mexican heroin volume entering the US, which was linked to the opioid crisis.

?Limited ResearchThe true number of patients addicted to Oxycontin through different pathways is unknown.

◐Partially SupportedRestricting access to prescription opioid painkillers could inadvertently harm patients who legitimately need them for chronic pain management.

◐Partially SupportedSome individuals do not become addicted to opioids even when exposed, suggesting a biological component to addiction susceptibility.

◐Partially SupportedThe original formulation of Oxycontin could be crushed, leading users to chew pills for faster pain relief.

◐Partially SupportedPurdue Pharma argued that iatrogenic addiction to Oxycontin, when prescribed by a doctor for a legitimate condition and taken as instructed, is vanishingly rare.

◐Partially SupportedPhysicians theorized that many afflictions have a chemical basis and could have chemical solutions.

◐Partially SupportedRichard Sackler believed there was no ceiling effect with OxyContin, allowing patients to continuously increase doses.

◐Partially SupportedDoctors are prescribing opioid painkillers less frequently, for shorter courses, and at lower doses.

◐Partially SupportedRelapse is a significant issue with opioid drugs.

◐Partially SupportedA change in social environment, such as new friends or relocation, may be crucial for sustained recovery from addiction.

◐Partially SupportedOxycodone is stronger than hydrocodone and morphine.

◐Partially SupportedNeurontin (gabapentin) is a non-addictive medication for neuropathic pain that can be sedating.

◐Partially SupportedPurdue Pharma released a non-crushable Oxycontin in 2010 after original patents expired.

◐Partially SupportedThe opioid crisis has caused approximately half a million deaths in the last two decades.