Why I Wouldn't Take Glycine Before Bed

PS

Paul Saladino3m · 2025-08-29

Claims Made

12

Claims Supported

7

Support Rate

58%

Support rate

7 of 12 claims supported

7 supported5 partial / not

Claims from this content

12

Well SupportedTaking Magnesium Threonate (145mg), Magnesium Bisglycinate (200mg), Apigenin (50mg), or Theanine (100-400mg) 3-4 nights per week, 30-60 minutes before bed, may aid sleep.Well SupportedPaul Saladino eats two meals a day, typically his last meal before 4 p.m., skipping dinner.Well SupportedTaking glycine 30-60 minutes before bed may improve subjective sleep quality.Well SupportedSpending extended periods outdoors and receiving significant sun exposure improves sleep quality, independent of step count.Not Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Excess glycine consumption can deplete methyl groups in individuals with methylation polymorphisms, potentially interacting with methylation processes.

Partially SupportedMagnesium 3-onate is the most effective form of magnesium for sleep for Paul Saladino.

Partially SupportedAdequate daily intake of calories, carbohydrates, and protein stabilizes blood sugar at night, leading to better sleep.

Partially SupportedConsuming honey right before sleep may be beneficial for some individuals.

Not SupportedA low protein day can lead to blood sugar dips during the night, potentially causing poorer sleep.

Partially SupportedConsuming a tablespoon of honey before sleep does not negatively affect sleep.

Partially SupportedPaul Saladino is cautious with glycine intake to avoid methyl group depletion due to MTHFR and taking methylated B vitamins.

Partially SupportedIndividuals without methylation polymorphisms are unlikely to experience issues with glycine's interaction with methylation.