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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Improving Sexual & Urological Health in Males and Females | Dr. Rena Malik — Whalespan

Content›Video›Improving Sexual & Urologica…

Improving Sexual & Urological Health in Males and Females | Dr. Rena Malik

Andrew Huberman2h 55m · 2023-08-14

Claims Made

306

Claims Supported

216

Support Rate

71%

Support rate

216 of 306 claims supported

216 supported90 partial / not

Claims from this content

241

✓Well SupportedAG1 is a vitamin, mineral, probiotic drink with adaptogens designed to meet foundational nutritional needs and provide insurance for adequate fruit and vegetable intake.✓Well SupportedAndrew Huberman drinks Athletic Greens twice a day, typically once in the morning and again in the afternoon or late afternoon, mixed with water and lemon or lime juice.✓Well SupportedInside Tracker's platform provides actionable protocols to adjust blood markers into ideal ranges for health.✓Well SupportedInside Tracker's platform helps users understand blood test data and provides protocols to adjust numbers into ideal ranges.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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✓

Quality sleep, regulated by core body temperature changes, is foundational for mental health, physical health, and performance.

✓Well SupportedThe Helix Dusk Mattress is reported to improve sleep depth, duration, and quality.

✓Well SupportedMattress characteristics like softness, firmness, and breathability significantly impact sleep quality and should be tailored to individual needs.

✓Well SupportedSleep is the foundation of mental health, physical health, and performance, and optimizing sleep is crucial for happiness, productivity, and overall life quality.

✓Well SupportedErectile dysfunction can precede cardiovascular events by approximately seven years, necessitating a cardiovascular health assessment for organic impotence.

◐Partially SupportedUnder U.S. regulations, supplements must meet their labeled dose by expiration, but melatonin's instability requires manufacturers to add overage to ensure compliance.

✓Well SupportedLow-dose tadalafil (2.5-5mg daily) can help with urinary symptoms and erectile function.

✓Well SupportedSex increases prolactin levels post-coitus, promoting calm and potentially facilitating pair-bonding.

✓Well SupportedOptimizing breathing and light viewing behavior are prerequisites for discussing supplements, diet, and other methods to improve testosterone, estrogen, and fertility.

✓Well SupportedThe prevalence of erectile dysfunction increases with age, with approximately 40% of men at 40, 50% at 50, 60% at 60, and 70% at 70 experiencing some degree of ED.

✓Well SupportedLibido tends to increase in women prior to and during ovulation, coinciding with the optimal time for fertility.

✓Well SupportedHigh oxalate foods such as spinach, almonds, and turmeric powder may contribute to the development of kidney stones.

✕Not SupportedOvertraining Kegels can lead to pelvic floor dysfunction.

✓Well SupportedDesire and arousal should be considered separate concepts in understanding sexual function, particularly for women, as treatments and research directions differ.

✓Well SupportedOral contraceptives may cause low libido in women by increasing SHBG, reducing testosterone availability.

✓Well SupportedPlant-based diets may benefit kidney health by maintaining an alkaline system that promotes citrate release in urine, a protective compound against stones.

✓Well SupportedEstrogen is neuroprotective and helps preserve brain function by maintaining blood vessel pliability.

✓Well SupportedSensation and nerve receptor sensitivity decrease with age.

✓Well SupportedInside Tracker's ultimate plan includes APO B and insulin measurements for cardiovascular health and energy regulation.

✓Well SupportedTestosterone generally collaborates with and increases the action of dopamine in both males and females.

◐Partially SupportedAG1 sponsorship includes an offer of five free travel packs plus a year supply of vitamin D3K2.

◐Partially SupportedCervical orgasm can occur from stimulation of the cervix and is characterized by measurable pelvic floor contractions.

◐Partially SupportedFlibanserin (Addyi) works on serotonin and dopaminergic areas of the brain.

✓Well SupportedApproximately 15-25% of women orgasm from penetration alone, while 70-85% require clitoral stimulation.

✓Well SupportedSSRIs and other antidepressants can disrupt sexual function, particularly desire and ejaculation, in a dose-dependent manner.

◐Partially SupportedTongkat Ali may enhance libido and potentially override SSRI-induced reduction in libido.

✓Well SupportedNighttime erections in men can indicate organ function independent of psychogenic factors.

✓Well SupportedBremelanotide may improve sexual desire, arousal, and satisfaction.

◐Partially SupportedThe Coolidge effect applies to females, where they regain the desire and ability to mate after exhaustion if presented with a new male partner.

✓Well SupportedPornography use activates dopamine pathways, potentially leading to a cycle of seeking more novel or intense content.

◐Partially SupportedExcessive daily masturbation to pornography since adolescence can hinder the development of competence and desirability in men.

◐Partially SupportedHabituation to specific vibratory stimulation during masturbation may impair arousal during penetrative intercourse.

◐Partially SupportedA pelvic floor exam involves palpating muscles and observing their function, including assessing tenseness, tenderness, and coordination of contraction.

✓Well SupportedElevated SHBG levels can persist for at least four months after discontinuing oral contraceptives.

✓Well SupportedDoppler ultrasounds of the penis and clitoris can assess blood flow by measuring peak systolic velocity and end-diastolic velocity.

✓Well SupportedPalpating the pelvic floor muscles laterally to the prostate during a rectal exam can reveal tightness and bands of muscle, indicative of pelvic pain syndrome.

◐Partially SupportedErectile dysfunction can be influenced by vascular, hormonal, neurological, psychogenic issues, and medications.

✕Not SupportedVaping and smoking are detrimental to erectile function and general sexual health in both males and females because nicotine is a vasoconstrictor.

◐Partially SupportedThe arousal response is initiated by parasympathetic tone, shifting towards sympathetic nervous system activity as arousal progresses.

◐Partially SupportedThe vaginal estrogen ring is an effective option for low estrogen states, lasting for three months after insertion.

✕Not SupportedSourcing peptides online from unverified sources can be dangerous due to contaminants.

◐Partially SupportedOnly about 3% of erectile dysfunction cases are directly related to hormonal issues.

✓Well SupportedTestosterone and hormonal balance are important for sex drive in men and women.

◐Partially SupportedDopamine in the nucleus accumbens is central to sexual desire and pursuit.

◐Partially SupportedAntidepressants like Wellbutrin, stimulants like cocaine, and ADHD medications like Adderall and Vyvanse increase dopamine levels.

✕Not SupportedNicotine use can lead to decreased penile girth and damage to endothelial tissue, impairing blood flow.

✓Well SupportedDysfunctional pelvic floor muscles can lead to difficulties with urination, incontinence, pain during sexual activity, or changes in orgasmic function.

◐Partially SupportedA healthy pelvic floor supports pelvic organs and is integral to urination, defecation, sexual function, and posture.

◐Partially SupportedExperiencing orgasm as a whole-body response or localized is due to individual nerve and sensation patterns originating from the brain.

◐Partially SupportedImproper breathing during exercise can lead to pelvic floor dysfunction.

✓Well SupportedTransdermal testosterone can be prescribed off-label for postmenopausal women with low libido if other causes are ruled out and testosterone levels are low.

◐Partially SupportedPelvic floor dysfunction can decrease blood flow and cause nerve inflammation in the pelvic region, affecting sexual function and causing pain.

◐Partially SupportedPsychogenic feedback loops can contribute to erectile dysfunction.

◐Partially SupportedKegels are prescribed for urinary incontinence and pelvic organ prolapse in women.

✓Well SupportedPainful intercourse can occur if adequate arousal time is not achieved before penetration.

◐Partially SupportedThe post-orgasm surge in prolactin levels contributes to the refractory period in males.

◐Partially SupportedThere is no objective benchmark for determining normal, high, or low libido; it is a subjective assessment.

◐Partially SupportedCaffeine, alcohol, and other bladder irritants can worsen symptoms of an enlarged prostate or overactive bladder.

✓Well SupportedTestosterone has a more direct link to sex drive than estrogen.

◐Partially SupportedWalking more or using a standing desk can help mitigate the negative effects of prolonged sitting on pelvic floor function.

◐Partially SupportedTo prevent cycling-related genital numbness and dysfunction, use a noseless or wider bike seat and maintain good posture.

✓Well SupportedDuring sexual arousal, the cervix moves up and out of the way, and the inner two-thirds of the vagina lengthens and elongates.

◐Partially SupportedA starting dose for Kegels is 10 to 15 repetitions, performed once or twice daily, with an optional third session mid-day.

✓Well SupportedWomen experience clitoral engorgement and nocturnal tumescence during sleep.

◐Partially SupportedMicrobiomes exist not only in the gut but also in other areas like the eyes, mouth, and nasal passages, with species varying along the digestive tract.

◐Partially SupportedCommon causes of erectile dysfunction include high blood pressure, diabetes, and atherosclerosis, which impair blood flow to the penis.

✓Well SupportedVaginal estrogen is highly effective and safe for reducing recurrent UTIs in women with low estrogen states by lowering vaginal pH through increased lactobacilli conversion of glycogen.

✓Well SupportedVaginal estrogen is safe and has not been associated with adverse events like breast cancer, uterine cancer, or blood clots due to minimal absorption.

◐Partially SupportedShilajit supplementation increased follicle-stimulating hormone (FSH) in a study.

✓Well SupportedWomen have a higher risk of UTIs than men due to having a shorter urethra.

◐Partially SupportedScents and pheromones produced by individuals can play a role in attraction and pair bonding.

✓Well SupportedA penile prosthesis should ideally be implanted within three months of priapism onset to avoid significant fibrosis.

✕Not SupportedL-citrulline can trigger canker sores and oral lip cold sores in sensitive individuals.

◐Partially SupportedThe refractory period after mating encompasses difficulty in achieving erection and potentially bypasses dopamine aspects.

◐Partially SupportedMedications like Flomax can be used to treat kidney stones by relaxing ureteral smooth muscle, aiding stone passage.

◐Partially SupportedTrimix is a medication injected into the penis to treat erectile dysfunction.

◐Partially SupportedAlpha-blockers like Flomax are effective medications for treating prostate issues.

✕Not SupportedDouching or internal vaginal cleaning methods can disrupt the vaginal microbiome and increase UTI or bacterial vaginosis risk.

✕Not SupportedThe feminine hygiene industry markets products that misrepresent normal physiological discharge and odor as unhealthy.

✕Not SupportedThe vagina is a self-cleaning organ and only requires washing the hair-bearing areas with soapy water.

✕Not SupportedMelanocyte-stimulating hormone (MSH) can cause priapism when injected.

✕Not SupportedEngaging in anal sex after using drugs impairs consent and safety awareness.

✕Not SupportedSpermicides, whether used alone or on condoms, are a known risk factor for recurrent UTIs in women.

✕Not SupportedCeasing Kegel exercises was beneficial for Andrew Huberman's pelvic floor health.

◐Partially SupportedThe vagina can lengthen and elongate to nearly double its baseline length to prepare for penetration.

◐Partially SupportedThere is no known evidence that oral contraception can disrupt neurotransmitters.

◐Partially SupportedHypoactive sexual desire disorder is defined as low libido that causes distress and bother.

◐Partially SupportedOnly 3-6% of erectile dysfunction cases are primarily hormonal in origin.

◐Partially SupportedAlcohol is a bladder irritant, and its effect on bladder contraction is dose-dependent.

◐Partially SupportedTongkat Ali, Maca root, and Shilajit can be tried one at a time for sexual health, with effects potentially building over time.

◐Partially SupportedWomen who take Tongkat Ali have reported improvements in libido and desire.

◐Partially SupportedL-citrulline is a reasonably effective supplement.

◐Partially SupportedTongkat Ali has reasonable supporting data for its efficacy.

◐Partially SupportedKidney stones can be caused by dehydration combined with metabolic abnormalities leading to increased calcium or oxalate in the urine.

◐Partially SupportedEndothelial dysfunction can present as cardiovascular problems or issues in sexual organs.

✕Not SupportedSuppressing estrogen with drugs like anastrozole in men can lead to a complete loss of libido.

◐Partially SupportedCompounded estrogen-testosterone cream applied to the vulvar vestibule can reduce pain and discomfort in women with vestibulodynia caused by hormonal imbalances.

◐Partially SupportedThe levator ani muscles contract during climax in both males and females.

◐Partially SupportedCentrally acting medications are available for premenopausal women with low libido.

◐Partially SupportedUp to 50% of women experience at least one UTI in their lifetime, and up to one-third experience recurrent UTIs.

◐Partially SupportedIntense exercise like heavy squatting or deadlifting can lead to erectile dysfunction or pain during intercourse due to pelvic floor hypercontraction and reduced blood flow.

◐Partially SupportedVaginal estrogen therapy for UTIs requires consistent application for approximately three months to become effective.

◐Partially SupportedConsuming two to three liters of fluid per day helps prevent UTIs by diluting bacteria and promoting frequent urination.

◐Partially SupportedFlibanserin (Addyi) is a daily 100mg medication taken at bedtime that works on serotonin and dopaminergic pathways to treat hypoactive sexual desire disorder.

◐Partially SupportedVaginal dilators with Valium or baclofen can help manage pelvic floor dysfunction symptoms by relaxing muscles.

◐Partially SupportedSexually transmitted infections are more likely with anal sex than vaginal penetrative intercourse due to thin and friable anal tissue.

◐Partially SupportedIf an exercise or practice worsens symptoms, it may be performed incorrectly or be unsuitable for the individual.

◐Partially SupportedImproving diet, cardiovascular and resistance training, and good sleep can boost testosterone and are valuable for sexual health.

◐Partially SupportedThe effective dose of testosterone for women is approximately one-tenth of the dose required for men.

◐Partially SupportedIt is difficult for most people to recognize pelvic floor tightness because it develops gradually and they are not trained to recognize the sensation.

◐Partially SupportedAvoiding abdominal exercises that involve crossing the legs may alleviate pelvic floor discomfort.

◐Partially SupportedPDE5 inhibitors like Viagra and Cialis work by preventing the breakdown of cGMP, which leads to longer-lasting erections.

◐Partially SupportedIUDs are generally safe and effective forms of contraception, despite small procedural risks associated with insertion.

◐Partially SupportedCarbonated, spicy, and acidic foods can irritate the bladder lining and limiting them may be helpful.

◐Partially SupportedIntracavernosal injections like Trimix are the most effective nonsurgical treatment for erectile dysfunction.

◐Partially SupportedTo avoid trauma during anal sex, start with a smaller girth item and gradually increase size.

◐Partially SupportedYoung, healthy patients can become critically ill within 24 hours due to kidney stones, requiring ICU admission.

◐Partially SupportedTrue priapism is exceedingly rare in individuals taking Cialis or Viagra for erectile dysfunction.

◐Partially SupportedMedications like Cialis or Viagra have a success rate of about 60% to 70% in treating erectile dysfunction.

◐Partially SupportedThe pelvic floor is a muscle that is difficult to recognize and train, unlike Kegel exercises which are commonly discussed.

◐Partially SupportedStrengthening a strong pelvic floor further can be detrimental, whereas strengthening a weak pelvic floor is beneficial.

◐Partially SupportedIndividuals experiencing symptoms like painful urination, pain with erections or ejaculation, or difficulty emptying should consult a urologist to assess their pelvic floor.

◐Partially SupportedExercise for aesthetic reasons can lead to pelvic floor hypercontraction, causing pain during intercourse and other dysfunctions.

◐Partially SupportedMassage, vaginal dilators, or muscle relaxant suppositories can temporarily relax a tight pelvic floor in women.

◐Partially SupportedWorking with a physical therapist is the best approach to down-train the pelvic floor using exercises like 'happy baby pose'.

◐Partially SupportedTestosterone cream applied to the clitoris in postmenopausal women may increase sexual desire and the number of sexually satisfying events.

◐Partially SupportedLow-dose daily Cialis/tadalafil can be a reasonable intervention for women experiencing sexual dysfunction with signs of vascular problems to try for at least four weeks.

◐Partially SupportedReducing the dose of SSRIs, switching to Wellbutrin, or using Cialis and Viagra can help manage SSRI-related sexual dysfunction.

◐Partially SupportedFlibanserin (Addyi) is a daily 100mg medication taken at bedtime that helps decrease hypoactive sexual desire disorder in 45% to 60% of patients.

◐Partially SupportedLow-dose tadalafil (Cialis) is effective for Benign Prostatic Hyperplasia (BPH).

◐Partially SupportedTrazodone can be used off-label as a third or fourth-line treatment for premature ejaculation.

◐Partially SupportedNot all women are aroused by G-spot stimulation, similar to how not all men enjoy prostate stimulation.

◐Partially SupportedHormonal axis alterations, breastfeeding, and post-menopause can cause vaginal lubrication changes independent of arousal.

◐Partially SupportedPost-climax, the body shifts to the parasympathetic nervous system, facilitating pair bonding through oxytocin and vasopressin.

◐Partially SupportedOral contraceptives and antidepressants are frequently cited as causes of low libido and orgasmic difficulties in females.

◐Partially SupportedOral contraceptives can cause sexual dysfunction, with low-dose estrogen formulations being common culprits.

◐Partially SupportedPost-menopause, decreased estrogen and testosterone levels can lead to reduced vaginal lubrication.

◐Partially SupportedBremelanotide can be prescribed off-label for men experiencing delayed ejaculation to help them achieve orgasm more effectively.

◐Partially SupportedSitting to urinate can be beneficial for complete bladder emptying, especially for men with enlarged prostates or pelvic floor dysfunction.

◐Partially SupportedErectile dysfunction, pelvic floor dysfunction, and vaginal lubrication issues can be influenced by hormonal, blood flow, and neural factors.

◐Partially SupportedL-citrulline and L-arginine increase nitric oxide availability, which is upstream of the cGMP pathway involved in erections.

◐Partially SupportedVaginal lubrication can occur independently of libido or sexual arousal and should not be misinterpreted.

◐Partially SupportedCranberry extract containing 36mg of soluble proanthocyanidins (PACs) is effective in reducing the risk of recurrent UTIs in women.

◐Partially SupportedTechniques like sitting, relaxing, leaning forward, and attempting to void a second time can help ensure complete bladder emptying.

◐Partially SupportedPelvic floor dysfunction can manifest as urinary urgency, frequency, leakage, difficulty urinating, or incomplete bladder emptying.

◐Partially SupportedPelvic floor muscles can become contracted and short due to overuse, stress, anxiety, or posture problems, leading to dysfunction.

◐Partially SupportedUsing a condom and adequate lubrication during anal sex is important because the anus does not produce endogenous lubrication.

◐Partially SupportedD-mannose, taken at 2 grams per day, can help reduce UTI risk and has been shown effective in small randomized controlled trials.

◐Partially SupportedKegel exercises involve contracting the pelvic floor muscles, described as pulling up and in the vagina or lifting the penis off the floor.

◐Partially SupportedRecreational use of Kegels can lead to more intense pelvic floor contractions during orgasm, potentially increasing pleasure.

◐Partially SupportedKegels should not be performed during urination to avoid dysfunction.

◐Partially SupportedMasturbation can offer benefits such as improved sleep, mood boosting, and anxiety reduction if not excessive.

◐Partially SupportedHormone dysregulation is responsible for a very small percentage of sexual dysfunction.

◐Partially SupportedAssessing hormone panels, including free testosterone and total testosterone, is valuable for identifying symptoms of low testosterone such as depression, weight gain, poor muscle mass gain, and cognitive changes.

◐Partially SupportedNovelty can impact the arousal response.

◐Partially SupportedMaca root may influence sexual desire through dopaminergic tone changes or estrogen receptor modulation.

◐Partially SupportedShilajit quality and dosing are challenging to distinguish and determine.

◐Partially SupportedResponse to oral contraception is highly individual.

◐Partially SupportedCialis (tadalafil) and Viagra are sometimes used off-label in females for sexual dysfunction to address blood-flow issues and difficulties with orgasm.

◐Partially SupportedApomorphine is approved outside the US for sexual response enhancement but not in the US.

◐Partially SupportedLimiting caffeine intake may improve urinary symptoms because caffeine is a bladder irritant.

◐Partially SupportedViagra was initially studied for high blood pressure and its erectile effect was discovered incidentally.

◐Partially SupportedMycoplasma can cause urinary tract infection symptoms and may warrant testing if standard treatment fails.

◐Partially SupportedDuring vaginal stimulation, the clitoral crura and shaft are often stimulated due to the clitoris's wishbone-like structure.

◐Partially SupportedFemale orgasms can be graded and cumulative, or they can be 'cliff-type' with a refractory period.

◐Partially SupportedThe deeper two-thirds of the vagina has less innervation than the outer third, and cervical stimulation can lead to orgasm.

◐Partially SupportedUreteroscopy for kidney stones involves inserting a camera through the urethra under anesthesia to break up stones with a laser.

◐Partially SupportedGenetic factors, such as a family history of enlarged prostate, increase the likelihood of developing an enlarged prostate.

◐Partially SupportedAssessable indicators of sexual function in women include lubrication levels, pain during sex, and ability to orgasm.

◐Partially SupportedAn enlarged prostate can narrow the urethra, making urination difficult.

◐Partially SupportedA new, strong, fishy body odor may indicate a sexually transmitted infection.

◐Partially SupportedSome individuals can achieve orgasm through nipple stimulation alone, or from auditory or visual stimuli.

◐Partially SupportedErection in males and clitoral tumescence in females are primarily blood flow events.

✕Not SupportedAndrew Huberman concluded that avoiding Kegels was beneficial for his pelvic floor after experiencing painful urination.

✕Not SupportedIf experiencing symptoms like painful urination or pain with erections/ejaculation, stop Kegels and consult a urologist.

◐Partially SupportedTadalafil (Cialis) can be used as an adjunct treatment for erectile dysfunction by improving blood flow and being continuously available due to its long half-life.

◐Partially SupportedIndividuals seeking pelvic floor assessment should look for urologists board-certified in female pelvic medicine and reconstructive surgery or specialists in sexual medicine.

◐Partially SupportedMedications for erectile dysfunction are effective in 60% to 70% of cases, influenced by usage, dosing, and psychological factors.

◐Partially SupportedA stimulus is required to trigger nitric oxide release via the parasympathetic nervous system, which is essential for erections.

◐Partially SupportedPelvic floor dysfunction from prolonged sitting can cause erectile issues in young men.

◐Partially SupportedThe traditional sexual response model involves parasympathetic activation for initiation and sympathetic activation for progression.

◐Partially SupportedIncomplete bladder emptying can lead to bacteria growth and recurrent UTIs.

◐Partially SupportedKidney stones accompanied by infection symptoms, fever, or chills require immediate treatment due to the risk of rapid deterioration.

◐Partially SupportedPelvic-floor and blood-flow issues can cause sexual dysfunction in males and females.

◐Partially SupportedThe climax response, potentially including ejaculation, is associated with the body's stress system.

◐Partially SupportedThe erection and vaginal lubrication responses are typically generated by the parasympathetic nervous system.

◐Partially SupportedPreventative measures for kidney stones include increasing fluid intake to 2-3 liters daily and decreasing oxalate intake.

◐Partially SupportedFinding pelvic floor physical therapists specializing in male anatomy is important.

◐Partially SupportedNitric oxide acts as the ignition for erections.

◐Partially SupportedProblematic pornography use, defined as overuse leading to negative impacts on real-world sexual interactions, is identified in approximately 4% of individuals in studies.

◐Partially SupportedThe Coolidge effect, where a novel sexual partner can override a refractory period and allow for subsequent sexual activity, is present in both males and females.

◐Partially SupportedThe recovery period after orgasm can include a refractory period where further orgasm or erection is not possible.

◐Partially SupportedDuring the excitement phase of female sexual response, heart rate and breathing increase, a sex flush may appear, and vaginal lubrication begins.

◐Partially SupportedFemale orgasm involves increased sympathetic response and rhythmic pelvic floor muscle contractions approximately every 0.8 seconds.

◐Partially SupportedAbout 40% of people qualify for sexual dysfunction based on validated questionnaires, but only about 12% report significant bother.

◐Partially SupportedThe female sexual response cycle includes phases of excitement, plateau, orgasm, and recovery.

◐Partially SupportedImproving erections may potentially help alleviate depression.

◐Partially SupportedThe body has a protective mechanism that immediately creates lubrication when there is any sense of potential penetration to avoid trauma and injury.

◐Partially SupportedMore scientific research on Shilajit is needed to support its use.

◐Partially SupportedCottage cheese-like vaginal discharge, itching, or discomfort can indicate yeast or bacterial infections and warrant medical evaluation.

◐Partially SupportedWater-based lubricants are accessible, silicone-based are more slippery and last longer, and oil-based last longer but are not condom-compatible.

◐Partially SupportedNon-STI infections are not strongly associated with anal sex compared to other forms of intercourse.

◐Partially SupportedSymptoms of an enlarged prostate can include urinary urgency, increased frequency of urination, and nocturia.

◐Partially SupportedResponses to orgasm vary, with some individuals becoming sleepy, others energized, some experiencing heightened desire, and others becoming hypersensitive to touch.

◐Partially SupportedThe G-spot is an erogenous zone in the anterior vaginal wall associated with the Skene's glands.

◐Partially SupportedOral contraceptives offer benefits for sexual freedom, pregnancy prevention, and managing conditions like PCOS.

◐Partially SupportedEnsuring complete bladder emptying is important for UTI prevention.

◐Partially SupportedPelvic floor weakness can result from childbirth, neurological disorders, or connective tissue disorders and lead to urinary incontinence.

◐Partially SupportedCommon causes of priapism include intracavernosal injections, trazodone, and sickle cell anemia.

◐Partially SupportedL-citrulline has better bioavailability and lasts longer in the bloodstream than L-arginine.

◐Partially SupportedCopper acts as a spermicide, making copper IUDs effective contraception.

◐Partially SupportedAASect.org is a resource for finding a sex therapist.

◐Partially SupportedUse iso-osmolar lubricants for anal sex.

◐Partially SupportedThe brain is the most powerful organ for sex, more so than the genitals.

◐Partially SupportedMany people need to relax their pelvic floor rather than strengthen it for proper urologic and sexual function.

◐Partially SupportedExcessive cleaning of the genital area can cause contact dermatitis.

◐Partially SupportedDrugs that increase dopamine can cause desire but inhibit physical arousal like erections or lubrication.

◐Partially SupportedOral contraceptives can lead to depressive-like symptoms, anhedonia, and apathy by increasing sex hormone-binding globulin and reducing free testosterone and estrogen.

◐Partially SupportedAlertness, aggression, or excitement (adrenaline) can stimulate erection or vaginal lubrication in some individuals.

◐Partially SupportedThe Mediterranean diet is the best-studied diet for improving sexual dysfunction.

◐Partially SupportedA healthy pelvic floor includes muscular and neuromuscular components and adequate blood flow.

✕Not SupportedBike seats with cutouts may not be beneficial and can sometimes increase pressure around the opening.

◐Partially SupportedExpectations for supplements like Tongkat Ali and Ashwagandha should be tempered due to smaller study sizes and potential bias.

◐Partially SupportedAshwagandha is beneficial for stress reduction, which has implications for sexual function.

◐Partially SupportedLow-dose daily tadalafil may be prescribed for prostate health by improving blood flow and potentially lowering prostate cancer risk.

◐Partially SupportedPercutaneous nephrolithotomy is a procedure for large or hard kidney stones using a small incision in the back to break up and remove the stone with ultrasonic lithotripsy.

◐Partially SupportedFemale orgasm can be achieved through clitoral stimulation during penetration, stimulation of the outer vagina, or direct clitoral stimulation.

◐Partially SupportedHydronephrosis combined with signs of infection necessitates prompt treatment for kidney stones.

◐Partially SupportedOvercleaning the genital area can disrupt the local microbiome and increase UTI risk.

◐Partially SupportedDecreasing protein intake, particularly from purine-rich meats, can reduce the risk of kidney stones.

◐Partially SupportedKegel exercises strengthen the pelvic floor by contracting muscles used to stop urination, but should not be practiced during urination.

◐Partially SupportedPelvic floor therapists align bones and posture to normalize pelvic floor function.

◐Partially SupportedBeginners should perform Kegels lying down to focus solely on the pelvic floor muscles, then progress to sitting and standing positions.

◐Partially SupportedThe rate of erectile dysfunction is not significantly different between runners, swimmers, and cyclists.

◐Partially SupportedYoung people may develop unrealistic expectations about sex due to a lack of comprehensive sex education, leading them to believe pornography depicts normal sexual interactions.

◐Partially SupportedAkkermansia muciniphila supplementation may improve gut-barrier integrity and metabolic markers in older adults.

◐Partially SupportedInformation about sex learned from unreliable sources can be misleading or detrimental.