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The effect of alcohol consumption on health (AMA #1) — Whalespan

Content›Video›The effect of alcohol consum…

The effect of alcohol consumption on health (AMA #1)

Peter Attia10m · 2020-01-18

Claims Made

19

Claims Supported

4

Support Rate

21%

Support rate

4 of 19 claims supported

4 supported15 partial / not

Claims from this content

15

✓Well SupportedOne alcoholic drink in the evening does not impact sleep, but two or more drinks profoundly increase resting heart rate and decrease heart rate variability.✓Well SupportedAlcohol suppresses REM sleep at all doses, reducing its crucial role in long-term memory formation.◐Partially SupportedA standard drink is defined as 12 oz beer, 5 oz wine, or 1-1.5 oz hard liquor.✕Not SupportedThe Intervention Testing Program (ITP) tested resveratrol using concentrations suggested by David Sinclair, and it did not extend lifespan in regular mice.Not Supported

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Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✕

Alcohol has no biochemical requirement in the body and has not been observed to improve any important function.

◐Partially SupportedEthanol is a toxin whose impact on a population follows a probability distribution.

◐Partially SupportedAldehyde, a byproduct of ethanol metabolism, is a toxin that affects both the liver and the brain.

◐Partially SupportedThe liver's metabolic pathway for ethanol overlaps significantly with that of sugar or fructose.

◐Partially SupportedA single glass of wine per day might offer a net benefit by reducing cortisol and emotional distress.

◐Partially SupportedSome individuals exhibit genetic outlier tolerance to alcohol, maintaining normal liver function despite consuming very high quantities.

◐Partially SupportedEthanol's effect on the central nervous system is experienced as a 'buzz' and CNS depression, acting as a GABA agonist.

◐Partially SupportedPeter Attia's rule is to consume only high-quality, exceptional alcohol for a specific purpose.

◐Partially SupportedThe amount of resveratrol in a glass of red wine is insufficient to provide the longevity benefits observed in high-concentration lab studies.

◐Partially SupportedDrinking alcohol can lead to increased consumption of unhealthy foods.

◐Partially SupportedAn ALT level at the upper limit of normal suggests potential fatty liver related to ethanol or fructose intake.