The Intervention Testing Program (ITP) tested resveratrol using concentrations suggested by David Sinclair, and it did not extend lifespan in regular mice.

“even if you believe those data which I categorically do not and no lab has ever been able to reproduce them and I'm not even convinced that Sinclair today would believe that those were valid”

“we tested it um because um the director of the national aging Institute Richard hotus for the first time last time said you will test Resveratrol or you will not get anybody this year we said yes sir yes sir so we we tested it we used we checked with David Sinclair and asked David what is the concentration we ought to use he said use this concentration and this concentration we said sure we'll do it your way let's find out and it didn't work and subsequently many groups now including groups that Dr Sinclair is associated with have shown that it doesn't work to extend lifespan of regular mice”

“I think the failure of RIS veratrol in the ITP I think you view as dispositive that that drug never worked in any circumstance anywhere it doesn't work in humans it doesn't work in mice”