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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Why VO2 max is the greatest predictor of lifespan | Peter Attia — Whalespan

Content›Video›Why VO2 max is the greatest …

Why VO2 max is the greatest predictor of lifespan | Peter Attia

Peter Attia6m · 2024-01-16

Claims Made

11

Claims Supported

10

Support Rate

91%

Support rate

10 of 11 claims supported

10 supported1 partial / not

Claims from this content

9

✓Well SupportedVO2 max is the greatest predictor of lifespan, surpassing other biomarkers and health factors like smoking, diabetes, kidney disease, heart disease, and hypertension.✓Well SupportedHigh VO2 max, muscle mass, and strength are superior predictors of lifespan compared to cholesterol, blood pressure, blood glucose, and smoking.✓Well SupportedMoving from below-average to above-average VO2max is associated with a 41% increased risk of all-cause mortality.✓Well SupportedMaintaining a high VO2 max in one's 40s and 50s is important for potentially extending lifespan by a decade due to inevitable decline.Well Supported

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Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Achieving elite VO2 max levels for one's age group requires maintaining a standard significantly higher than the current age bracket's minimum.

◐Partially SupportedVO2 max represents the cumulative effect of training as the integral of work over time.

✓Well SupportedAn individual's VO2 max cannot be significantly improved in just one month of training, unlike easily manipulated biomarkers.

✕Not SupportedBiomarkers like VO2 max or strength are more indicative of longevity potential than easily manipulated biomarkers such as vitamin D levels.

◐Partially SupportedAnyone can achieve a top 25% VO2 max for their age and sex with sufficient training history.