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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Is there a net benefit of plant compounds for medicinal purposes? — Whalespan

Content›Video›Is there a net benefit of pl…

Is there a net benefit of plant compounds for medicinal purposes?

Paul Saladino8m · 2022-04-09

Claims Made

19

Claims Supported

13

Support Rate

68%

Support rate

13 of 19 claims supported

13 supported6 partial / not

Claims from this content

15

✓Well SupportedConsuming plants without considering their chemical defenses can pose a significant health risk.✓Well SupportedPlant molecules can have side effects when they interact with human biology.◐Partially SupportedSulforaphane from various sources can have side effects.◐Partially SupportedSome individuals may experience autoimmune conditions triggered by plant compounds, while others may have triggers from animal compounds.✓Well Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Humans may achieve significant health benefits without consuming plant compounds, potentially avoiding negative side effects.

◐Partially SupportedThe net benefit of plant compounds should be assessed considering both harms and risks, and whether they offer redundant benefits.

✓Well SupportedStatins inhibit HMG-CoA reductase and their benefit may extend beyond LDL reduction.

◐Partially SupportedAstaxanthin inhibits 5-alpha reductase 2, which may warrant caution when combining it with other supplements.

◐Partially SupportedTurmeric may decrease testosterone levels and act as a mild anti-androgen, potentially interacting with AR more than inhibiting steroidogenesis.

◐Partially SupportedTurmeric may affect potassium channels, p53, and thyroid hormone reductase.

◐Partially SupportedNon-protein amino acids from plant foods may accumulate in the body and cause protein misfolding, potentially contributing to neurodegeneration.

◐Partially SupportedBerberine is a molecule derived from bark that can have physiological effects in humans.

◐Partially SupportedBaseline metabolic health, oxidative-reductive balance, and inflammatory states can influence the need for external interventions like sulforaphane.

◐Partially SupportedGeneral antioxidants may not prevent DNA damage in healthy humans because endogenous mechanisms are often sufficient.

◐Partially SupportedThe long-term effects of plant compounds in the human body are not fully understood and warrant investigation.